Brain Exercise Enhancement Laboratory
Current Research Projects
Currently, the lab’s research projects are focused on a few different areas, with all of them relating to the effects of supplementation on the brain. Below, you'll find the current studies we have or are upcoming, and you can read a project description. If you have more questions, feel free to reach out!
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The effect of exercise-induced lactate on BDNF and cognition
Background
A single bout of exercise can rapidly improve cognitive functions including memory, and executive function post-exercise, which help us navigate through everyday life. However, we do not yet fully understand the mechanism behind this process.
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Purpose
We aim to investigate how lactate produced during a single bout of exercise affects the production of a neurotrophin called brain-derived neurotrophic factor (BDNF) and cognitive abilities following exercise.
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Methods
Participants will ingest sodium bicarbonate to produce more lactate in the blood while performing the same exercise.
Significance:
This study will help us isolate the effect of lactate on brain function in young adults and contribute to our understanding of how exercise improves brain health.
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Clinical Trials Preregistration: https://clinicaltrials.gov/study/NCT06817681
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If you are interested in participating, please contact Addriana Odisho at odisha2@mcmaster.ca
The effect of exogenous β-OHB supplementation on cerebral blood flow and functional brain characteristics in adults with subjective cognitive decline
Background
People with subjective cognitive decline (SCD) have a particularly greater risk of developing dementia. Currently, there is a lack of effective interventions to mitigate that risk.
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Purpose
Our trial will investigate if short-term ketone monoester (KME) supplementation can improve brain function and cognition in older adults with SCD.
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Methods
Participants will complete two separate 14-day interventions consisting of thrice-daily consumption of a placebo or KME supplement. Brain MRI scans, cognitive tests, and blood samples will be collected before and after each intervention.
Significance:
This trial will critically inform guidelines for the potential therapeutic use of KME to reduce dementia risk in SCD.